Validated targets for personalized cancer immunotherapy

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What are the characteristics of a cancer cell that are recognized by the immune system? Knowledge of the potential target structures for the immune cells is a basic prerequisite for the development of personalized cancer immunotherapies. Scientists are publishing a highly sensitive method based on mass spectroscopy to identify such tumor-specific ‘neoepitopes’. The analytical method is designed to detect these low abundance protein fragments and requires minimal amounts of sample material.

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